Director - Institute of Genetic Engineering

ige.badu@gmail.com
+91 (33) 2526 0051 / 52 / 53 / 60
First College in West Bengal started Biotechnology and Genetics courses
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Amit Chakravarty
Prof (Dr) Amit Chakravarty
Director / Founder Principal
M. Sc. In Biochemistry
Ph. D. in Medical Biochemistry

Dr. Amit Chakravarty Profile & Portfolio

Qualification
Date of Birth :
17th July, 1947

Highilights of Qualification
  • M.Sc In Biochemistry (Bombay University)
  • Ph.D in Medical Biochemistry (Bombay University)
    (From Grant Medical College & J. J. Hospital, Mumbai.)

Certified Professional in
  • Medical Genetics (John Hopkins Medical School, USA)
  • * Molecular Cytogenetics (Cambridge University)
  • Molecular Genetics (Institute of Molecular Medicine, Oxford University, UK)
  • Plant Tissue Culture (Pune University.)
  • Advance course in Assisted Reproductive Technology (National University Hospital, Singapore)
  • Prenatal Diagnosis (European Society Of Genetics Italy)
  • Obstetric Ultrasound (Queen Memorial Hospital Glasgow).
Position / Posts
POST - DOC Training
  • Institute of Molecular Medicine, Oxford (UK).
  • Dept. of Pathology , Cambridge University, UK
  • MRC Genetics Unit, Western General Hospital, Edinburgh, UK.
  • MRC Reproductive Biology Unit, Edinburgh, UK.
  • Biochemical Genetics Unit, Royal Hospital Sick Children, Edinburg, UK.
  • Dept. of Obst. & Gynec.Kings College Hospital, Denmark Hill, UK.
  • IVF (Embryology) - Bourn Hall, Cambridge, UK.
  • Dept of Obst 7 gynec.,,Baylor College of Medicine , Houston, USA
  • Reproductive Genetics Institute, Chicago, USA
  • Clinical & Molecular Genetics Laboratory, College of Medicine ,University of Tennessee, USA
  • New York Blood Center, New York, USA
  • CBSC-CryoBank, UCLA, USA.
Experiences in Diagnostic and Research Laboratory
Experiences in Diagnostic and Research Laboratory
  • 30 yrs. of experiences in Genetic Counseling and Prenatal Diagnosis of Genetic Disorders ( USA / UK /India ) and trained in following areas in Medical Genetics :
  • Clinical Cytogenetics and Molecular Cytogenetics.
  • DNA analysis and PCR based Molecular Diagnosis.
  • Animal and Human Cell Culture.
  • Assisted Reproductive Technology & Cry preservation.
  • Fish Breeding & Genetic Modification.
Field of Research Interest
Field of Research Interest

  • *Molecular Cytogenetics (FISH/ HR-CGH) in Clinical Genetic.
  • Genomic Instability in Cancer
  • Pre-implantation Genetics Diagnosis.
  • Pre-conception Genetic Diagnosis.
  • Stem Cell transplantation in Cancer and Thalassaemia.
  • Gene Therapy and Stem cells Reasearch
  • Genomics of Complex Genetic Disorders ( Diabetes / Cancer)
  • Genomic Instability of Mental Retardation
Field of Research Interest
Experience in Teaching

  • Ex-Reader in Biochemistry at Grant Medical College & Sir J.J. Group of Hospitals Bombay
  • Teaching program in various Institutions in USA & UK.
  • PG Teaching & Research
  • PG Examiner & Ph.D Thesis Examiner.(University of Mumbai)
  • Ex-Prof. & Head, Biotechnology Dept, INSTITUTE OF TECHNOLOGY MARINE ENGINEERING, KOLKATA.
ASSOCIATION MEMBERSHIP
ASSOCIATION  MEMBERSHIP

  • Board Member, International Society for Prenatal diagnosis
      • Indian Society for Human Genetics.
  • Fellow, Indian College of Maternal and Child Health.
      • Indian Society of Perinatology.
  • Founder Member & Secretary, Indian Society For Prenatal Diagnosis & Therapy. India
PUBLICATIONS
PUBLICATIONS

  • 319  papers (upto year  2009)
Published Books and Contributed chapters in Medical Books
Published  Books and Contributed chapters in Medical Books

  • Human  Cytogenetic  Techniques and  Clinical  application, Bhalani  Publiishing  House, Mumbai ,2000
  • Genetics of  Thalassaemia ; Diagnosis, Management &Prevention ; Thalassaemia Foundation ; 2002
  • Recent Advancement in Obst. & Gynec. ; Dasgupta(ed)
  • Prenatal Diagnosis and Therapy ; Ed itor ; Proceeding of 8th International Conference on Prenatal Diagnosis of  Genetic Disorders ; Jaypee Brothers ; 1998
  • * A Chapter in ‘Pregnancy At Risk-Current Concepts’ (Published in 1993) By Usha Krishna / Shirish Daftary
  • Chapter : *An Introduction To Genetics And Fetal Medicine (Published in 1996) Editor Kamini A. Rao.
  • Chapters : 1. Genetic Counseling And Multifactorial Inheritance,
  • Chapters : 2. Laboratory Techniques In Prenatal Diagnosis Of Genetic Disorders.
  • “Role of Genetic Investigations and Counseling
  • Test Book of Pediatrics (Published in 1991, Re-edition Jan. 1998)  Editor – Dr. P. M. Udani. Editor, Fetal Medicine & surgery ; ISPAT News Letter.
  • Preventive Genetics ; Chapter ; Jaypee ; 2006

PAPER PUBLISHED
PAPER PUBLISHED

  1. Sudipa Basu & Amit Chakravarty : Population screening of Thalassaemia – A Preliminary report ; 15th  National Congress of Perinatology ; 3 – 4th April, (1999).
  2. Sudipa Basu and Amit Chakravarty : Thalassaemia trait in our population; BOGS regional annual conference ; Kalyani ; 21st August, (1999).
  3. Sudipa Basu and Amit chakravarty : Thalassaemia Screening : BOGS Annual Conference, Kolkata ,27th February, (2000).
  4. Sudipa Basu and Amit Chakravarty : Population screening of Thalassaemia in Eastern part of India; 2nd International Conference on Thalassaemia;  New Delhi; (2000).
  5. Amit Chakravarty, Hema Purandarey, Sharad Gogate, Raju Sahetya, Gopal Jaiswal, Pranab Dasgupta, K Ghosh, S Mishra, S Dasgupta. Prenatal diagnosis of genetic disorders – Indian multi-centric experience. ISPD, Barcelona (Spain) (2002)
  6. Amit Chakravarty and Sudipa Basu  :  Thalassaemia Screening in Eastern part of India ; ISPAT Annual Congress ; Pune ; 16th January, (2002).
  7. Sudipa Basu Chakravarty and Amit Chakravarty : Genetic Screening and Prevention of Thalassaemia in Indian population ; ISPD ; Japan ; (2002).
  8. Amit Chakravarty, Hema Purandarey, Sharad Gogate, Raju Sahetya, Gopal Jaiswal, R P Soonawala, Pranab Dasgupta, Sudipa Chakravarty. Prenatal diagnosis of genetic disorders – a multi-centric Indian data. ISPD, Japan (2002)
  9. Jhimli Dasgupta, Udayaditya Sen, Debi Choudhury, Poppy Datta, Abhijit Chakrabarti, Sudipa Basu Chakravarty, Amit Chakravarty and J.K.Dattagupta: Crystallization and Preliminary X-ray structural studies of Haemoglobin A2 and Haemoglobin E, isolated from the blood samples of beta-thalassemic patients;Biochemical Biophysical Research Communications.(2003).
  10. Poppy Datta, Sudipa Basu Chakravarty, Amit Chakravarty and Abhijit Chakrabarti: Interaction of erythroid spectrin with hemoglobin variants: Implications in beta–Thalassemia; Blood Cells, Molecules & Diseases, (2003).
  11. Udayaditya Sen, Jhimli Dasgupta, Debi Choudhury, Poppy Datta,| Abhijit Chakrabarti,| Sudipa Basu Chakrabarty, Amit Chakrabarty, and Jiban K. Dattagupta. Crystal Structures of HbA2 and HbE and Modeling of Hemoglobin  ‰4: Interpretation of the Thermal Stability and the Antisickling Effect of HbA2 and Identification of the Ferrocyanide Binding Site in Hb‡ Biochemistry; (2004).
  12. Poppy Dutta, Sumanta Basu, Sudipa Basu Chakravarty, Amit Chakravarty, Debashish Banerjee, Sharmila Chandra, Abhijit Chakrabarti. Enhanced oxidative cross-linking of hemoglobin E with spectrin and loss of erythrocyte membrane asymmetry in hemoglobin Eb-thalassemia. Blood, Cells and Molecules (2006)
  13. Poppy Dutta, Sudipa Chakravarty, Amit Chakravarty and Abhijit Chakrabarti. Spectrin interactions of globin chains in presence of phosphate metabolites and hydrogen peroxide : Implications in Thalassemia. J of Bioscience. (2007)
  14. Dipankar Bhattacharya, Sutapa Saha, Sumanta Basu, Sudipa Chakravarty , Amit Chakravarty , Debashis Banerjee & Abhijit Chakrabarti. Differential regulation of redox proteins and chaperones in erythrocyte proteomes with varying severity of HbEβ-thalassemia. Blood, Cells & Molecules (accepted for publication) (2009)
  15. Population Screening strategies for Thalssaemia in Eastern India ; Experience of 19,762 cases ; Sudipa Chakravarty, Tridip Chatterjee and Amit Chakravarty ; Institute of Genetic Engineeering, Kolkata ; Birth Defects & Disabilities in The Developing World ; 4th International Conference; New Delhi, India, 4-7 Oct, 2009
  16. Application of HR-CGH in Chromosomal Aberrations ; Amit Chakravarty, Sudipa Chakravarty, Puspal De, Arun Singh ; Institute Of Genetic Medicine and Genomic Science,Kolkara-128 ; Birth Defects & Disabilities in The Developing World ; 4th International Conference; New Delhi, India, 4-7 Oct, 2009
  17. Hb-E Beta thalassaemia- wide spectrum of clinical severity in Eastern Inia & Prospective Management ; Sudipa Chakravarty, Tridip Chatterjee, Dipankar bhattacherjee, Sutapa Saha, Sumanta basu, Abhijit Chakraborty, Amit Chakravarty ; Institute of Genetic Engineering, Structural Genomics Divisionn, Saha Institute of Nuclear Physics; Kolkata ; Birth Defects & Disabilities in The Developing World ; 4th International Conference; New Delhi, India, 4-7 Oct, 2009
  18. Study of Molecular Background favorable for Hydroxyurea Therapy in Hb-E-beta Thalassaemai patients ; Sudipa Chakravarty, Ritushree Kukreja , Amit Chakravarty, Harpeet Kaur ; Institute of Genetic Engineering , Kolkata ; Functional Genomic unit, Institute Genomics and Integrative Biology, New delhi ; Birth Defects & Disabilities in The Developing World ; 4th International Conference; New Delhi, India, 4-7 Oct, 2009
  19. Fetal Chromsomal Anomalies Detected in 10,480  CVS cases ; A Multicentric Prenatal Diagnosis Indian Data ; Amit Chakravarty, Hemat Purandarey, Sudipa Chakravarty ; Institute of Genetc Medicine and Genomic Science, Kolkata; Centre of Genetic Health Care, Mumbai ; Birth Defects & Disabilities in The Developing World ; 4th International Conference; New Delhi, India, 4-7 Oct, 2001
  20. Higher HbF Production during Pregnancy may be a cause due to escape of inactivation of “ FCPX( Xp 22.3) ; Joyita Mukherjee, Kamalesh Roy, Tridip Chatterjee, Amit Chakravarty Sudipa Chakravrty;  Institute of Genetic Engineering, Badu, Kolkata700126;  10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  21. Herapeutic approach of Resveratrol : A noble HbF Inducer Mimicking the Biological Activity of Hydroxyurea ; Madhuparna Hore*, Tridip Chatterjee*, Anirban Roychowdhury+, Amit Chakravarty+ and Sudipa Chakravarty* ; Institute of Genetic Engineering, Badu, Kolkata700126;  10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  22. Fetal DNA Analysis for NNAT (Imprinted gene) – a Prenatal diagnostic approach in predicting Pituitary adenoma in the fetus : Bioinformatics approach ; Anindita Ray+, Tridip Chatterjee+,Sudipa Chakravarty+,  Amit Chakravarty* ;; Institute of Genetic Medicine and Genomic Science, Kolkata  ; 10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  23. Antenatal Screening criteria for Thalassaemia trait (beta and HbE) in pregnant women in Eastern Indian population ; Anirban Roychowdhury*, Tridip Chatterjee+, Amit Chakravarty* and Sudipa Chakravarty^ Institute of Genetic Medicine and Genomic Science badu, Kolkata ; 10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  24. Dilemmas in Prenatal diagnosis of β-Thalassaemia in Eastern India   ; Amit Chakravarty and Sudipa Chakravarty ; Institute of Genetic Medicine and Genomic Science badu, Kolkata ; 10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  25. Role of HbE in study of Clinical severity among HbE-β thalassaemia cases – Genomic and Proteomic approach ; Tridip Chatterjee*, Dipankar Bhattacharya#, Sutapa Saha#, Sumanta Basu#, Abhijit Chakrabarti#, Amit Chakravarty*, Sudipa Chakravarty* ; Institute of Genetic Medicine and Genomic Science badu, Kolkata ; 10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  26. To study Genomic stability in Mental Retardation by HR-CGH; Amit Chakravarty, *Puspal De, *Sudipa Chakravarty, **Arun Singh  ; Institute of Genetic Medicine and Genomic Science badu, Kolkata ; 10th Annual Conference of Indian Society of Prenatal Diagnosis; 3-4th April, 2010 ; Hotel Mariot; Mumbai
  27. Role Probiotics in Obesity Diagnosis and Management ; Amit Chakravarty and Sudipa Chakravarty; Institute of Genetic Medicine and Genomic Science badu, Kolkata ;34th Annual Conference of Indian Association Medical Microbiologists ;24-28th November,2010 ; Swabhumi, Kolkata
  28. Genetic Assessment of Human Embryos ; Amit Chakravarty and Sudipa Chakravarty; Institute of Genetic Medicine and Genomic Science badu, Kolkata ; 16th National Congress of Indian Society for Assisted Reproduction ; 4-6th March, 2011 at Hotel Jaypee Palace; Agra
  29. Biology in Silico- Bioinformatics Resources for Health Science Research – International  Workshop in collaboration with Health Science Library System, Pittsburgh University (USA)- Amit Chakravarty- Course Coordinator ; 9-10th August, 2011 Institute of Genetic Medicine and Genomic Science Badu, Kolkata
  30. Detection of Genomic Imbalances by High Resolution comparative Genomic Hybridization in Neonate witj Multiple Malformation ; Pushpal De, Sudipa Chakravarty, Gorachand Bhattacheriya , Amit Chakravarty ; Institute of Genetic Medicine and Genomic Science Badu, Kolkata and Calcutta National Medical College, Kolkata ; International Conference on  ‘Omics Meet Disease’ and 3rd Annual Meeting of Proteomics- Society (India); December 15-18, 2011 at Saha Institute of Nuclear Physics, Kolkata
  31. Detection of CNVs by HR-CGH and Diagnostic Correlation in Haematological Cancer ;  Somhita Choudhery, Sudipa Chakravarty, Ashok Bhadra and Amit Chakravarty ; Institute of Genetic Medicine and Genomic Science Badu, Kolkata and  Dept of Radio-Diagnosis Bangur Institute of Neuro-Science, Kolkata ; International Conference on  ‘Omics Meet Disease’ and 3rd Annual Meeting  of Proteomics- Society (India); December 15-18, 2011 at Saha Institute of Nuclear Physics, Kolkata
  32. Genomics and Proteomics Based case Study of a Thalassaemic Family showing unusual pattern of transfusion requirement ; Tridip Chatterjee, Suchismita Halder,  Amit Chakravarty, Sudipa Chakravarty and Abhijit Chakrabarti ; ; Institute of Genetic Medicine and Genomic Science Badu, Kolkata and  Structural Genomics Division , Saha Institute Nuclear Physics, Kolkata ; International Conference on  ‘Omics Meet Disease’ and of Proteomics- Society (India); December 15-18, 2011 at Saha Institute of Nuclear Physics, Kolkata
  33. Genome Wide Analysis for Genetic Instability in Haematological Cancer ; Somhita Choudhery, Sudipa Chakravarty Ashok Bhadra and Amit Chakravarty ; ; Institute of Genetic Medicine and Genomic Science Badu, Kolkata and  Dept of Radio-Diagnosis Bangur Institute of Neuro-Science, Kolkata; 99th  Indian Science Congress ; 3-7th  January, 2012, KIT  University, Bhubaneshwar , Orissaa
  34. Evaluation of a new Oral Herbal Iron Chelator Phytic Acid in Thalassaemia ; Anwesha Bhowmick Amit Chakravarty, Tapan Kr Chatterjee and Sudipa Chakravarty ; Institute of Genetic Engineerin, Badu, Kolkata and Dept of Pharmaceutical Technology Jadavpur University, Kolkata ;  99th  Indian Science Congress ; 3-7th  January, 2012, KIT  University, Bhubaneshwar , Orissaa
  35. Altered Hb Switching in Beta and Hb E- beta thalassaemia pattern ; Tridip Chatterjee Amit Chakravarty Sudipa Chakravarty ; Institute of Genetic Medicine and Genomic Science Badu, Kolkata; 99th  Indian Science Congress ; 3-7th  January, 2012, KIT  University, Bhubaneshwar , Orissaa
  36. Ilamas in considering β-Thalassemia status in subjects with borderline HbA₂ values: a pilot study in Eastern India; Tridip Chatterjee, Amit Chakravarty, Sudipa Chakravarty; Thalassemia Reports 2014: vol 4(s1):2103.
  37. Mutational Spectrum of Thalassemias and other Hemoglobinopathies in West Bengal, Eastern India; Tridip Chatterjee, Amit Chakravarty, and Sudipa Chakravarty ; Hemoglobin, 2014; 38(6): 405–408.
  38. Differential regulation of plasma proteins between members of a family with homozygous HbE and HbEβ-thalassaemia; Suchismita Halder, Tridip Chatterjee, Amit Chakravarty, Sudipa Chakravarty, Abhijit Chakrabarti; Thalassemia Reports 2014: vol 4(s1):1837.
  39. Clinical Presentation of two Beta-Thalassaemic Indian Patients with 1p 36 Deletion Syndrome- Case Report; Puspal De, Tridip Chatterjee, Sudipa Chakravarty and Amit Chakravarty; Journal of Pediatric Genetics; 2014.
  40. Population Screening and Prevention Strategies for Thalassaemias  and other Haemoglobinopathies of Eastern India: Experience of 18,166 cases; Tridip Chatterjee, Amit Chakravarty, Sudipa Chakravarty; Hemoglobin 2015, DOI :10.3109/03630269.2015.1068799.
  41. Mutational Spectrum of thalassaemia in Chittagong, Southeastern part of Bangladesh; Tridip Chatterjee, Amit Chakravarty, Sudipa Chakravarty, Mahmood Ahmed chowdhury, Razia Sultana; Hemoglobin 2015, DOI:10.3109/03630269.2015.1078810.
ACHIEVEMENTS
ACHIEVEMENTS

  1. Established First Private Genetic Diagnostic Centre at Bombay India In 1981.
  2. Established 2 other Private Genetic Diagnostic Centre in India (Pune & Calcutta)
  3. Conducted Workshops Thro’ INDIAN SOCIETY OF PRENATAL DIAGNOSIS INDIA in Different States in India
  4. Awarded Fellowship, Indian College of Maternal and Child Health.
  5. Founder Trustee of ‘Biotech Foundation’ & established “Institute of Genetic Engineering”.and Institute of Genetic Medicine and Genomic Science, at Kolkata
  6. Organising Secretary ; International Conference of International Society for Prenatal Diagnosis (ISPD) ; Goa;1996
  7. Trained More Than 50 Medical Doctors & Scientists in Human Cytogenetics & Molecular Genetics.
REFERENCES
REFERENCES

  1. Prof. Joe .L. Simpson.  Dept. Obst. &  Gynec. , Baylor  College  Medicine , Houston , USA
  2. Dr John Old, Intitute of Molecular Medicine,Oxford University
  3. Dr Avirachan  Tharapel , Clinical & Molecular  Genetics , Dept. of  Pediatrics, University  of  Tenessee, USA
  4. Prof. M.Ferguson Smith, Dept. of  Pathology, University  of  Cambridge, UK
  5. Prof. Charles  Rodeck , Dept. Obst. & Gynec, UCL, London, UK
  6. Dr Subir Dutta , Senior Consultant Pathologist, Kolkata
  7. Dr B.N.Chakraborty, Director,Institute of Reproductive Medicine, Salt Lake, Kolkata
  8. Dr Manish Chakraborty, Ex-Director; Institute of Tropical Medicne; Kolkata
PRESENT POSITION
PRESENT POSITION

  1. Director ,Institute of Genetic Engineering, Kolkata-700128
  2. Director , Institute of Genetic Medicine and Genomic Science, Kolkata - 700128
Reach me
Reach me
  • Mobile : +919903850960
  • Email :   ige.amit@gmail.com
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