BSC - Genetics - Institute of Genetic Engineering
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B.Sc in Genetics
Duration : 6 Semesters (Three Years)
Total Marks = 3600

Eligibility : For admission in B.Sc, students from science stream with 10+2 (HS exam) or equivalent (ISC, CBSE etc.) examination having Physics / Chemistry / Biology / Mathematics (any two Science subject is compulsory) and pass mark in each subject will be eligible.

B.Sc Degree Course (Hons) in Genetics

DURATION : Six Semesters (Three Years)
Total Marks = 3600

Theoretical Papers : 24 Papers (Marks = 2400)
Total Credit = 16 Credits per semester = 6 x 16 = 96

Practical / Project Papers : 12 papers (Marks = 1200)
Total Credit = 4 Credits per semester = 6 x 4 = 24

Total Credit in 6 Semesters = 96 + 24 = 120
4 credit (Theory) means 3 lecture hours & 1 Tutorial per week
or 42 lectures per semester per paper
2 credit (Lab.) means at least 40 hours of lab work per semester per paper
  1. In view of the increasing demand for training manpower in the area of Genetics, Molecular Biology, Genetic Medicine and Biotechnology, it was consensus of the committee (Faculties & experts) that this course should be broad based and should be able to give a good insight into modern biology and important component of hands-on training to the students. Thus by nature it will be an interdisciplinary course.
  2. a) For admission, students from Science stream with 10+2 (HS exam) or equivalent, ISC, CBSE exam will be eligible.
          b) Admission will be through selection test CET (Common Entrance Examination) and also on the basis of the merit.
          c) The number of students for this course to be admitted this year will be 30.
  3. The fee structure should be on no grant basis as applicable to technical courses.

BSc : Genetics (Hons) Syllabus

1st Semester - Paper (Theoretical) :
BSc Genetics - 1st Semester - Paper (Theoretical)

1st Semester - Paper (Practical) :
BSc Genetics - 1st Semester - Paper (Practical)
2nd Semester - Paper (Theoretical) :
BSc Genetics - 2nd Semester - Paper (Theoretical)

2nd Semester - Paper (Practical) :
BSc Genetics - 2nd Semester - Paper (Practical)
3rd Semester - Paper (Theoretical) :
BSc Genetics - 3rd Semester - Paper (Theoretical)

3rd Semester - Paper (Practical) :
BSc Genetics - 3rd Semester - Paper (Practical)
4th Semester - Paper (Theoretical) :
BSc Genetics - 4th Semester - Paper (Theoretical)

4th Semester - Paper (Practical) :
BSc Genetics - 4th Semester - Paper (Practical)
5th Semester - Paper (Theoretical) :
BSc Genetics - 5th Semester - Paper (Theoretical)

5th Semester - Paper (Practical) :
BSc Genetics - 5th Semester - Paper (Practical)
6th Semester - Paper (Theoretical) :
BSc Genetics - 6th Semester - Paper (Theoretical)

6th Semester - Paper (Practical) :
BSc Genetics - 6th Semester - Paper (Practical)

First Semester Syllabus

Paper Code : MSA –101 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Macromolecular Structure & Analysis
Lecture period : 42L

  1. Carbohydrates : Structural aspects – Introduction & Occurrence, Classification of Mono-, Di- and Polysaccharides, Reducing & Non-reducing Sugars, Constitution of Glucose & Fructose, Osazone formation, Pyranose & Furanose forms, Determination of ring size, Inter-conversion of mono-saccharides. (4 Periods)
  2. Lipids : Structural aspects – General introduction, Classification & Structure of Simple & Compound lipids, Properties of Lipid aggregates (elementary idea), Biological membrane, Membrane protein – structural aspects, Lipoproteins (elementary idea). (4 Periods)
  3. Proteins : Structural aspects – General introduction, Classification & General characteristics, Structure of Primary, Secondary, Tertiary & Quaternary proteins (elementary idea), a- & b- chains of proteins (elementary idea), Classification of Amino acids. (5 Periods)
  4. Nucleic acid : Structural aspects – Components of DNA and RNA, Nucleosides & Nucleotides (introduction, structure & bonding), Double helical structure of DNA (Watson-Crick model), various forms of DNA. (5 Periods)
  5. Chemical & Enzymatic Kinetics - An introduction to enzyme; How enzyme works; Reaction rate; Thermodynamic definitions; Principles of catalytic power and specificity of enzymes; Enzyme kinetics – Approach to mechanism. (5 Periods)
  6. Genes are DNA – DNA is the genetic material, DNA is a double helix, DNA replication is semi-conservative, mutations change the sequence of DNA, a gene codes for a single polypeptide, recombination occurs by physical exchange of DNA, genetic code is triplet. (5 Periods)
  7. Mutation – Occurrence, kinds of Mutation, spontaneous & induced Mutation, Mutagens, detection of Mutation, Lethal Mutations, Biochemical Mutations, Phenotypic effects of Mutation, Molecular basis of Mutation, Significance & Practical applications of Mutation. (4 Periods)
  8. Expression of genetic information : from Transcription to Translation - The Relationship between genes and protein, The transcriptions : The basic process, Transcription and RNA Processing in Eukaryotic Cells, Encoding genetic information, Decoding the codons : the role of transfer RNAs. (5 Periods)
  9. Regulation of mRNA stability – capping, polyadenylation, pre-mRNA splicing, formation of commitment complex, creation of catalytic sites, trans-esterification reactions, mRNA surveillance. (5 Periods)

Paper Code : BPI -102 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Biophysics & Instrumentation
Lecture period : 42L

  1. General Biophysical methods – Measurement of pH, Radioactive labeling & counting, Autoradiography. (3 Periods)
  2. Separation & Identification of Materials - concept of Chromatography (Partition Chromatography, Paper Chromatography, Adsorption Chromatography, TLC, GLC, Ion Exchange Chromatography, Gel Chromatography, HPLC, Affinity Chromatography); Electrophoresis (Gel Electrophoresis, Paper Electrophoresis). (8 Periods)
  3. Centrifugation – Basic Principle of Centrifugation, Instrumentation of Ultracentrifuge (Preparative, Analytical), Factors affecting Sedimentation velocity, Standard Sedimentation Coefficient, Centrifugation of associating systems, Rate-Zonal centrifugation, sedimentation equilibrium Centrifugation. (5 Periods)
  4. Microscopy – Light microscopy, Bright & Dark Field microscopy, Fluorescence microscopy, Phase Contrast microscopy, TEM, SEM. (6 Periods)
  5. X-Ray Crystallography – X-ray diffraction, Bragg equation, Reciprocal lattice, Miller indices & Unit cell, Concept of different crystal structure, determination of crystal structure [concept of rotating crystal method, powder method]. (6 Periods)
  6. Spectroscopy: Raman Spectroscopy – What is Raman effect, Quantum mechanical reason of Raman effect, Molecular Polarizability, Polarizability ellipsoid, Experimental technique of Raman effect, Basic concept of Pure Rotational & Vibrational, Raman spectra of simple molecule (linear molecule). NMR Spectroscopy – Basic principle of NMR spectroscopy, Experimental technique & instrumentation, Chemical shift, Hyperfine splitting, Relaxation process. Absorption Spectroscopy – Simple theory of the absorption of light by molecules, Beer-Lambert law, Instrumentation for measuring the absorbance of visible light, Factors affecting the absorption properties of a Chromophore. (14 Periods)

Paper Code : CSD -103 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Cell Structure & Dynamics
Lecture period : 42L

  1. Origin of life on Earth - The theory of Extraterrestrial contact - import of life through meteorites. Theory of Chemical Evolution, Primitive Earth Conditions - anoxic reductive atmosphere, relatively high temperature, Volcanic eruption, radioactivity, high frequency UV radiation. Abiotic formation of sugars, amino acids, organic acids, purines, pyrimidines, glycerol and formation of nucleotides and their polymerization to RNA on reactive Surfaces, polymerization of amino acids to Polypeptides and Proteins. Ribozymes and RNA World. Formation of DNA, Formation of nucleoproteins, Prions, Natural Selection of Self replicating Polymers. (8 periods)
  2. Basics of Cell Biology (structure & function) – Discovery of cell and Cell Theory; Comparison between plant and animal cells; Cell wall; Plasma membrane; Modification of plasma membrane and intracellular junctions; Cytoskeleton; Protoplasm; Mitochondria; Chloroplast; ER; Golgi complex; Lysosome, endosome and microbodies; Ribosome; Centriole; Nucleus; Chemical components of a cell; Catalysis and use of energy by cells. (10 Periods)
  3. Biogenesis of Cellular organelles – Biosynthesis of mitochondria, chloroplast, ER, Golgi complex; Biosynthetic process in ER and golgi apparatus; Protein synthesis and folding in the cytoplasm; Degradation of cellular components. (6 Periods)
  4. Structure and function of Prokaryotic cell & its components - The Slime and the cell wall of bacteria containing peptidoglycan and related molecules; the outer membrane of Gram-negative bacteria, the cytoplasmic membrane. Water and ion transport, mesosomes, flagella, Pilus, fimbriae, ribosomes, carboxysomes, sulfur granules, glycogen, polyphosphate bodies, fat bodies, gas vesicles; endospores, exospores, cysts. Mycelia of fungi and Actinomycetes, Cytoskeleton filament, heterocysts and akinets of Cyanobacteria, Gliding and motility. (8 Periods)
  5. Membrane structure & transport – Models of membrane structure, Membrane lipids, proteins and carbohydrates; Solute transport by Simple diffusion, Facilitated diffusion and Active transport (6 Periods)
  6. Cell cycle - An overview of cell cycle; Components of cell cycle control system; Intracellular and Extra-cellular control of cell division, Programmed cell death (Apoptosis), intrinsic & extrinsic pathways of cell death, Apoptosis in relation with Cancer, Viral disease (AIDS) & Organ transplant. (4 Periods)

Paper Code : BMT-104 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Biomathematics
Lecture period : 42L

Classical Algebra
  1. Complex Number including D’Moivre’s Theorem, Logarithm (only algebra, without Series expansion), Binomial Theorem (without infinite series).
  2. Determinant, Matrix, Rank of Matrices by Diagonalisation method. (12 Periods)

Calculus – I [For functions of single variable]

  • Limit, Continuity, Differentiation (including differentiability), Successive Differentiation, Expansion of Functions – Rolle’s theorem, Mean Value theorem, Integration – Definite and Indefinite (ordinary, method of substitution, special trigonometric function, partial fraction) Application of integration to find area, Differential equations --homogeneous and Linear ODE’s and its simple applications to biological problems. (20 Periods)

Calculus – II [For functions of two variables]

  • Partial Differentiation including Euler’s theorem and it’s application. (10 Periods)

Paper Code : BMI –192 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Basic Microscopy & Instrumentation
Practical period : 40

  1. Microscopy – Light microscopy : principles, parts & function, Operation. (5 Periods)
  2. Image analysis of different classes of Microbes. (5 Periods)
  3. Preparation of Microbial media (bacteria, yeast, mold, algae, protozoa) (5 Periods)
  4. Sterilization: principles & operations – Autoclave, Hot Air Oven, Filtration, Laminar Air Flow (4 Periods)
  5. Principles & operations of Incubators & Shakers (4 Periods)
  6. Principle & operation of Centrifuge (4 Periods)
  7. Principle & operation of pH meter (3 Periods)
  8. Principle & operation of Colorimeter (3 Periods)
  9. Principle & operation of Spectrophotometer (3 Periods)
  10. Electrophoresis techniques (4 Periods)

Paper Code : BCH–191 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Biochemistry
Practical period : 40

  1. Estimation of protein by Folin Lowry method (3 Periods)
  2. Determination of Km and V max of amylase. (4 Periods)
  3. TLC separation of Amino acids /sugars (3 Periods)
  4. Determination of Iodine number of a fat (3 Periods)
  5. Estimation of RNA by Orcinol method (3 Periods)
  6. Estimation of DNA by diphenyl amine method (3 Periods)
  7. Verification of Beer’s Law Spectrophotometrically (4 Periods)
  8. Testing of Blood Sugar (3 Periods)
  9. Testing of Liver Function Test (Bilirubin, SGOT, SGPT, Alkaline Phosphatase, Albumin, Globulin, Total Protein) (8 Periods)
  10. Testing of Renal Function Test (Urea, Uric acid, Creatine, Creatinine) (6 Periods)

Second Semester Syllabus

Paper Code : OMB-201 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Organic Mechanisms in Biology
Lecture period : 42L

  1. Common Mechanisms in Biological Chemistry – Overview of Digestion, Absorption, Metabolism (Anabolism & Catabolism), Nutrition, Photosynthesis, Respiration, Excretion. (4 Periods)
  2. Biomolecules – Carbohydrates (Anomaric carbon, Mutarotation, Simple Chemical reactions of Glucose, Reducing & Non-reducing Sucrose, Maltose & Lactose, Elementary idea of structure of Starch & Cellulose); Proteins (Denaturation of proteins, Enzyme Kinetics), Nucleic acids (Mechanisms of Replication, Transcription & Protein synthesis, Genetic code); Hormones (classification, structural features & functions in bio-systems); Vitamins (classification, functions of vitamins in bio-systems). (10 Periods)
  3. Lipid Metabolism – Structures and roles of Fatty acids & Glycerols, beta oxidation of saturated fatty acids, oxidation of unsaturated fatty acids, oxidation of odd chain fatty acids, energy yield, ketone bodies. (6 Periods)
  4. Carbohydrate Metabolism – Aerobic & Anaerobic glycolysis, sequence of reactions in glycolysis, regulation in glycolysis, citric acid cycle, glycogenesis, glycogenolysis (sequence of reactions & regulation), Pentose-phosphate pathway (sequence of reactions & regulation), extraction of energy from food sources. (8 Periods)
  5. Amino acid Metabolism – Amino acid breakdown (amino acid deamination, Urea cycle, metabolic breakdown of individual amino acids – glucogenic & ketogenic amino acids), amino acids as biosynthetic precursors (haem biosynthesis & degradation, biosynthesis of epinephrine, dopamine, seretonin, GABA, histamin, glutathione); biosynthesis of essential & non-essential amino acids. (8 Periods)
  6. Nucleotide Metabolism – biosynthesis of purine & pyrimidine (de novo & salvage pathway); degradation of purine & pyrimidine. (6 Periods)

Paper Code : PTG-202 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Principles of Transmission Genetics
Lecture period : 42L

  1. Science of Genetics – an overview of modern history of Genetics before 1860, 1860-1900, 1900-1944, 1944-Present, about 3 general areas of Genetics (Classical, Molecular & Evolutionary). (3 Periods)
  2. Mendelism & Chromosome Theory – Mendel’s principles, applications of Mendel’s principles, Chromosome Theory of Heredity (Sutton-Boveri), Inheritance patterns, phenomenon of Dominance, Inheritance patterns in Human (Sex-linked, Autosomal, Mitochondrial, Unifactorial, Multi-factorial). (4 Periods)
  3. Extension of Mendelism – Deviation from Mendel’s Dihybrid phenotype, Linkage, Sutton’s view on linkage, Morgan’s view on linkage, Bateson & Punnet’s Coupling & Repulsion hypothesis. (2 Periods)
  4. Linkage & Crossing over - Chromosome theory of Linkage, kinds of linkage, linkage groups, types of Crossing over, mechanism of Meiotic Crossing over, kinds of Crossing over, theories about the mechanism of Crossing over, cytological detection of Crossing over, significance of Crossing over. (3 Periods)
  5. Allelic Variation & Gene function – Multiple allele, Genetic interaction, Epiststic interactions, Non-Epistatic inter-allelic genetic interactions, Atavism/Reversion, Penetrance (complete & incomplete), Expressivity, Pleiotropism, Modifier/Modifying genes. (3 Periods)
  6. Non-Mendelian inheritance – Evidences for Cytoplasmic factors, cytoplasmic inheritance, extra-nuclear inheritance (mitochondrial, chloroplast), non-chromosomal inheritance, maternal inheritance, uniparental inheritance. (3 Periods)
  7. Chromosomal variation in Number & Structure – Euploidy, Non-disjunction & Aneuploidy, Aneuploid segregation in plants, Aneuploidy in Human, Polyploidy in Plants & Animals, Induced Polyploidy, applications of Polyploidy, Chromosomal Mosaics, Polytene chromosome in Diptera, Deletion, Duplication, Inversion, Translocation, Position Effect, Centromeric & Non-centromeric breaks in chromosomes, chromosomal rearrangements in Human being, Chromosomal aberrations & evolution. (4 Periods)
  8. Chromosome Mapping - Haploid mapping (2 point & 3 point cross), Diploid mapping (Tetrad analysis), determination of linkage groups, determination of map distance, determination of gene order, cytological mapping. (4 Periods)
  9. Human Cyto-Genetics – Human karyotype, Banding techniques, classification, use of Human Cyto-genetics in Medical science, Chromosomal abnormalities in spontaneous abortions, viable monosomies & trisomies, chromosomal deletions & duplications, genetics of chromosomal inversions & translocations, human traits, Genomic position effects on Gene expression. (4 Periods)
  10. Pedigree analysis – Symbols of Pedigree, Pedigrees of Sex-linked & Autosomal (dominant & recessive), Mitochondrial, Incomplete dominance & Penetrance. (4 Periods)
  11. Formulating & Testing Genetic Hypothesis –problems of Sex-linkage, problems of genes with Multiple alleles, problems of gene interactions, Chi-square, t-test. (8 Periods)

Paper Code : POM -203 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Principles of Microbiology
Lecture period : 42L

  1. Overview of history of Microbiology - Biogenesis and abiogenesis Contributions of Redi, Spallanzani, Needham, Pasteur, Tyndal, Joseph Lister, Koch [Germ Theory], Edward Jenner and Flemming [Penicillin], Scope of Microbiology. (4 Periods)
  2. Classification of Microbes - Systems of classification, Numerical taxonomy, Identifying characters for classification, General properties and principles of classification of microorganisms Systematics of bacteria, Nutritional types [Definition and examples]. Classification on the basis of oxygen requirement. (6 Periods)
  3. Concept of Sterilization - Definition of sterilization, dry and moist heat, pasteurization, tyndalization; radiation, ultrasonication, filtration. Physical and Chemical methods of sterilization; disinfection sanitization, antisepsis sterilants and fumigation. Determination of phenol coefficient of disinfectant. (6 Periods)
  4. Stains and staining techniques – Definition of auxochrome , chromophores, dyes, Classification of stains, Theories of staining, Mechanism of gram staining, acid fast staining, negative staining, capsule staining, flagella staining, endospore staining. (6 Periods)
  5. Microbes in Extreme Environment – Nature, special features of the thermophilic, methanogenic and halophilic Archaea; photosynthetic bacteria, Cyanobacteria some Archaea who live in extreme conditions like cold, and space. (6 Periods)
  6. Pathogenic Microorganisms – List of common bacterial, fungal and viral diseases of human beings [Name of the disease, causative pathogen, parts affected] (4 Periods)
  7. Basic concepts of Virology - General characteristics of viruses, differences between bacteria and viruses. Classification of viruses Physical and chemical Structures of different Viruses on the basis of capsid symmetry - enveloped (Herpes virus), helical (TMV) and icosahedral (Polyoma viruses), Capsids, complex (Bacteriophage, and Virion size, enveloped (Herpes), helical (TMV) and icosahedral (Polyoma), Capsids. (10 Periods)

Paper Code : PGN-204 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Plant Genetics
Lecture period : 42L

  1. Unique genetic features of plants - Ability to photosynthesize, Totipotency of plant cells, Hermaphroditism and ability to reproduce both sexually and asexually, Double fertilization, Polyploidy, Alternation of generations, Mitosis in haploid state. (4 Periods)
  2. Molecular Biology of Plant Reproduction - Molecular genetic basis of plant reproduction, Emphasis on understanding developmentally regulated gene expression as it relates to the major changes that occur during plant reproduction and on the genetic control of flowering. (3 Periods)
  3. Genes controlling flower development in Plants – genes responsible for steps of flower development, genes for floral organ identity, MADS-Box genes, molecular expression of floral organ genes, molecular expression of floral commitment genes, analyzing gene expression with in situ hybridization. (3 Periods)
  4. Regulatory Mechanisms in Plant Development - Molecular mechanisms whereby endogenous and environmental regulatory factors control development; emphasis on stimulus perception and primary events in the signal chain leading to modulated gene expression and cellular development. (4 Periods)
  5. Plant Genome Organization and Function - Analysis of Genomes by Reassociation Experiments, Repeated Sequences, Organization of Single-copy Sequences, Evolution of Repeated Sequences in Cereals, Estimating the Number of Expressed Genes, Chloroplast Genome Organization, Mitochondrial Genome Organization, RNA editing. (4 Periods)
  6. Principles & Techniques of Plant Breeding – The principles, methods and applications of plant breeding and genetics to the improvement of crop plants, Principles involved in breeding and maintaining economic crops; factors affecting the choice of breeding methods; alternative approaches through hybridization and selection. (5 Periods)
  7. Chromosome Manipulation in Plants - Chromosome engineering as related to fundamental problems in plant genetics and as applied to plant breeding. (3 Periods)
  8. Molecular Approaches for Potential Crop Improvement - Introduction of basic concepts of plant molecular biology and molecular techniques in current use, Organization and regulation of plant genes, gene cloning and analysis, transformation systems for plants, and molecular techniques for crop improvement. (3 Periods)
  9. Analysis of Plant Genome with Molecular Markers – Plant Genome structure, Evolutionary relatedness, Comparative Genome mapping, Physical & Genetic distances, Linkage Drag. (3 Periods)
  10. Analysis of Plant Gene expression with Transgenic plants – Agrobacterium-mediated transformation, introduction of foreign genes via Agrobacterium-mediated transformation, analyzing gene expression with Transgenic plants. (3 Periods)
  11. Cis-acting elements and Trans-acting factors – Regulatory sequences that control gene expression, Enhancer and Silencer elements, role of 3’ sequences, role of introns, conserved sequences in Eukaryotic promoters, Cis-acting elements, Trans-acting factors, cloning of a plant transcription factor, plant regulatory genes who can function as trans-acting factors, Tissue-Specific Binding of Trans-Acting Factors. (4 Periods)
  12. Transposon tagging of Plant genes – Mc Clintock and the Ac-Ds transposable elements of Corn, Cloning Maize Ac and Ds Elements, molecular features of Maize Ac/Ds system, Cloning the Cf-9 Gene of Tomato by Transposon Tagging. (3 Periods)
  13. Plant Genetic Engineering – Plant transformation, map-based cloning of Plant genes, molecular pharming, plantibodies, Reversible male sterility in plants, antisense RNA, Agricultural applications in developing countries. (3 Periods)
  14. Mapping Plant Genome with Molecular Markers – Classes of Molecular markers, detecting DNA polymorphisms, mapping & mapping populations, Genetics of mapping molecular loci, specialized mapping, mapping quantitative trait loci with molecular markers, application of molecular markers to Selection. (3 Periods)
  15. Forest Tree Genetics - Genetics, evolution, and improvement of forest trees; physiology and anatomy of trees, population structure, selection procedures and breeding strategies, selected case studies of tree improvement programs. (2 Periods)

Paper Code : CGT–292 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Cytogenetics Techniques
Practical period : 40

  1. Basic sterilization techniques required for Media preparation & Cytological techniques (5 Periods)
  2. Media preparation technique (6 Periods)
  3. Culture of Human, Plant & Animal cells (8 Periods)
  4. Preparation of Slides (5 Periods)
  5. Staining of Slides (6 Periods)
  6. Image analysis & Karyotyping (10 Periods)

Paper Code : MIC–293 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Microbiology
Practical period : 40

  1. Sampling and quantification of microorganisms in air, soil and water. (6 Periods)
  2. Isolation of bacteria [Streak plate, spread plate, pour plate, serial dilution] (6 Periods)
  3. Identification of microorganisms from the habitats [simple staining, differential staining, acid fast staining, capsule staining, spore staining and motility] (6 Periods)
  4. Observation of morphology - shape and arrangement of cells. (6 Periods)
  5. Methods of inoculation of different microbes in selective media. (6 Periods)
  6. Microscopic measurements, micrometer (ocular and stage), haemocytometer. (6 Periods)
  7. Microscopic study of phytoplanktons & zooplanktons. (2 Periods)

Third Semester Syllabus

Paper Code : MCG -301 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Microbial Genetics
Lecture period : 42L

  1. Prokaryotic Genomes - Physical organization of bacterial genomes (Structure of the bacterial nucleoid, Replication and partitioning of the bacterial genome and Genome of Archaea). (4 Periods)
  2. Mechanism of genetic exchange : Plasmid and bacterial sex, Types of plasmids (F Plasmid : a Conjugate plasmid’, Mobilization of Non-conjugative plasmid, R plasmid, Col plasmid Copy number and incompatibility), Episomes. Transposable elements (Insertion sequence and transposons, Integrons and Antibiotic-Resistance cassettes, Multiple Antibiotic Resistant bacteria, Mu–virus); Bacterial Genetics (Mutant phenotype, DNA mediated Transformation; Conjugation (Cointegrate Formation and Hfr Cells, Time–of–Entry Mapping, F’ Plasmid); Transduction (Generalized transduction, Specialized Transduction)- gene mapping. (12 Periods)
  3. Molecular Mechanism of gene regulation in prokaryotes - Transcriptional regulation in prokaryotes (inducible and repressible system, positive regulation and negative regulation); Operon concept – lac, trp, Ara operons. (6 Periods)
  4. Bacteriophages: Stages in the Lytic Life Cycle of a typical phage, Properties of a phage infected bacterial culture, Specificity in phage infection, E. coli PhageT4, E.coli Phage T7, E.coli phage lambda, Immunity to infection, Prophage integration, Induction of prophage, Induction & Prophage excision, Repressor, Structure of the operator and binding of the repressor and the Cro product, Decision between the lytic and lysogenic Cycles, Transducing phages, E.coli phage phiX174, filamentous DNA phages, Single stranded RNA phages, The lysogenic Cycle. (15 Periods)
  5. Bacteriophage Genetics - Benzer’s fine structure of gene in bacteriophage T4 : Plaque Formation and Phage Mutants, Genetic recombition in the lytic cycle, (concept of recon, muton, cistron). (5 Periods)

Paper Code : POI -302 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Principles of Immunology
Lecture period : 42L

  1. Immune Response - an overview, components of mammalian immune system, molecular structure of Immunoglobulins or Antibodies, Humoral & Cellular immune responses, T-lymphocytes & immune response (cytotoxic T-cell, helper T-cell, suppressor T-cells), T-cell receptors, genome rearrangements during B-lymphocyte differentiation, Antibody affinity maturation class switching, assembly of T-cell receptor genes by somatic recombination. (8 Periods)
  2. Regulation of immunoglobulin gene expression – clonal selection theory, allotypes & idiotypes, allelic exclusion, immunologic memory, heavy chain gene transcription, genetic basis of antibody diversity, hypotheses (germ line & somatic mutation), antibody diversity, alternate pathways of transcript splicing, variable joining sites & somatic mutation, role of antibody (alone, in complement activation & with effector cells), monoclonal antibodies. (8 Periods)
  3. Major Histocompatibility complexes – class I & class II MHC antigens, antigen processing. (3 Periods)
  4. Immunity to infection – immunity to different organisms, pathogen defense strategies, avoidance of recognition, inactivation of host-immune effector mechanisms (3 Periods)
  5. Immuno-techniques - Blood grouping, Antigen-Antibody reactions : agglutination, precipitation, immuno-electrophoresis, Coomb’s test, ELISA, RIA. (8 Periods)
  6. Vaccines & Vaccination – adjuvants, cytokines, DNA vaccines, recombinant vaccines, bacterial vaccines, viral vaccines, vaccines to other infectious agents, tumor vaccines, principles of vaccination, passive & active immunization, immunization programs & role of WHO in immunization programs. (5 Periods)
  7. Auto-immune diseases – autoimmunity & auto-immune diseases, factors contributing development of auto-immune diseases, mechanism of development, breakdown of self-tolerance, rejection of transplants, molecular mimicry, diagnosis & treatment of auto-immune diseases, replacement therapy, suppression of auto- immune processes, nature of auto-antigens, immunodeficiency, AIDS. (5 Periods)
  8. Immune Response of Plants. (2 Periods)

Paper Code : PAT-303 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Plant and Animal Tissue Culture Techniques and its application
Lecture period : 42L

  1. Introduction to Techniques - Introductory history, Laboratory organization, Media, Aseptic manipulation. (3 Periods)
  2. Basic concepts in cell culture - cell culture, Cellular Totipotency, Somatic Embryogenesis. (5 Periods)
  3. In vitro culture : approaches & methodologies - preparation steps for tissue culture, surface sterilization of plant tissue material, basic procedure for aseptic tissue transfer, incubation of culture. (5 Periods)
  4. Tissue nutrition : Growth Hormones - Plant cells (Composition of culture media, Growth hormones, Vitamins, Unidentified supplements, selection of media); Animal cells (substrate on which cells grow, Feeder layer on substrate, gas phase for tissue culture, media and supplements). (6 Periods)
  5. Tissue culture methodologies - Plant cells (Callus Culture, Cell Suspension Culture, Organ Micro-culture, plant micro-propagation, Somatic Embryogenesis); Animal cells (Source of tissue, primary culture, differentiation of cells, growth kinetics, animal cell lines and their origin and chracterization). (6 Periods)
  6. Cloning & Selection of specific cell types – cloning, somatic cell fusion and HAT selection, Medium suspension fusion, selection of Hybrid clone, production of monoclonal antibodies. (6 Periods)
  7. Organ Culture - Culture of embryonic organs, whole embryo culture, culture of adult organs. (7 Periods)

Paper Code : PEG-304 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Population and Evolutionary Genetics
Lecture period : 42L

  1. Allele frequencies - deriving genotypic & allelic frequencies, introduction to quantitative genetics, deriving allelic frequencies from molecular data, changes in allele frequencies. (3 Periods)
  2. Classical Ecological Genetics & Polymorphism - phenotypic & genotypic polymorphisms, transient polymorphism, balanced polymorphisms. (2 Periods)
  3. Random & Non-random mating – positive & negative assortative mating, role in population size & change in gene frequency. (2 Periods)
  4. Hardy-Weinberg method & its applications – calculating allelic frequencies, assumptions of Hardy-Weinberg equilibrium, proof of Hardy-Weinberg equilibrium, Generation time, testing for fit to Hardy-Weinberg equilibrium (5 Periods)
  5. Inbreeding & outbreeding - inbreeding co-efficient, genotype frequencies under inbreeding, uses & effects of inbreeding in farm animals, genetic consequences of inbreeding, reasons for inbreeding. (2 Periods)
  6. Random Genetic drift – definition, its effects in small & large populations, bottlenecking & founder effect, genetic drift simulation, genetic drift vs selection. (2 Periods)
  7. Genetic equilibrium – definition, conditions for its stability, deviation of it (evolution). (2 Periods)
  8. Selection – overview, types & subtypes, negative & positive selections, patterns of selection (stabilizing, disruptive, directional, balancing), mechanisms of selection (disassortative sexual selection, frequency dependent selection), overdominance, natural selection, artificial selection, ecological selection. (3 Periods)
  9. Models for Population Genetics – deterministic & stochastic models. (4 Periods)
  10. Synthetic theory of Evolution – Lamarckian evolution theory, Darwin’s theory of evolution, Neo-Darwinism, modern synthesis theory of evolution, Macroevolution & Microevolution. (3 Periods)
  11. Principles of Evolutionary Genetics - From Mendel to molecules: A brief history of evolutionary genetics, Epistasis and the conversion of genetic variances. (2 Periods)
  12. Human and great ape genetic history – Human-Ape comparisons. (2 Periods)
  13. Evolution of Genetic Diversity - natural variation, sources of genetic variation : chromosomes & crossing over, SNPs, mutation, deletion & rearrangements, recombination, transgenic, genetic drift & gene flow. (4 Periods)
  14. Molecular Evolution – general approaches, principles, detecting selection at molecular level, rates of molecular evolution, Weak selection on non–coding gene features, Evolution of eukaryotic genome structure, New genes, new functions: Gene family evolution and phylogenetics, Gene genealogies, causes of change in allele frequency, molecular study of phylogeny, neutral theory of molecular evolution, Gene function and molecular evolution. (5 Periods)
  15. Genetics of Speciation - Patterns and processes of speciation: The evolution of reproductive isolating barriers, Species concepts, Genetics of reproductive isolation and species differences in model organisms, The Dobzhansky–Muller model, Natural hybridisation, Potential Outcomes of Natural Hybridization, Population bottlenecks and founder effects, Models on the shifts in selection pressures experienced by bottlenecked populations, Theory of phylogenetic estimation, Philosophical and methodological differences in phylogenetics. (5 Periods)
  16. Our place in the Evolutionary tree – Evolution of Mitochondrial genome & the origin of Eukaryotic cells, Evolution of Eukaryotic Nuclear genome, genome duplication & large-scale chromosomal alterations, Evolution of the Human sex chromosomes, Evolution of Human DNA sequence families & DNA organization, Comparative mammalian genome organization & the evolution of modern humans. (4 Periods)

Paper Code : IMN–392 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Immunology
Practical period : 40

  1. Antigen-Antibody reactions – Agglutination (Blood grouping testing). (6 Periods)
  2. Antibody titration (Ouchterlony Double Diffusion). (6 Periods)
  3. Antigen-Antibody reactions – Immuno-electrophoresis, Rocket immuno-electrophoresis. (10 Periods)
  4. Antigen-Antibody reactions – Coomb’s test. (8 Periods)
  5. Antigen-Antibody reactions – ELISA. (10 Periods)

Paper Code : TCT–393 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Tissue Culture Techniques
Practical period : 40

  1. In vitro Culture - Washing & Sterilization, Preparatory steps for tissue culture, surface sterilization of plant material, basic procedures for Aseptic tissue transfer, incubation of culture. (8 Periods)
  2. Preparation of Culture media & Reagents - Media composition, Nutrition, Hormones. (8 Periods)
  3. Tissue Culture – Callus culture, Cell suspension. (8 Periods)
  4. Organ Micro-culture - Shoot tip, excised root, Leaf culture. (8 Periods)
  5. Plant micro-propagation – micro-culture of plants. (8 Periods)

Fourth Semester Syllabus

Paper Code : MOG-401 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Molecular Genetics
Lecture period : 42L

  1. How to clone a gene - What is clone, Overview of the procedure, Gene library, Hybridization. (4 Periods)
  2. Purification and Separation of nucleic acids – Extraction and Purification of nucleic acids, Detection and Quantitation of Nucleic acids, Gel Electrophoresis. (8 Periods)
  3. Cutting and Joining DNA – Restriction Endonucleases, Ligation, Alkaline Phosphate, Double Digest, Modification of Restriction Fragments ends, Other Ways of joining DNA Molecules. (6 Periods)
  4. Vectors – Plasmid vectors, Vectors based on the lambda Bacteriophage, Cosmids, M13 vectors, Expression vectors, Vectors for cloning and expression in Eukaryotic cells, Super vectors : YACs and BACs. (8 Periods)
  5. Amplifying DNA : PCR and Cell based DNA Cloning – The importance of DNA Cloning, PCR : basic features and application, Principles of Cell-based DNA Cloning, Cloning System for amplifying different sized fragments, Cloning System for producing single-stranded and mutagenized DNA. (8 Periods)
  6. Nucleic Acid Hybridization : Principle and application - Preparation of nucleic probes, Principle of Nucleic acid hybridization, Nucleic acid hybridization assays, and microarrays. (8 Periods)

Paper Code : CBB-402 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Computational Biology & Bio-informatics
Lecture period : 42L

  1. Introduction to Genomics - information flow in biology, DNA sequence data, Experimental approach to genome sequence data, genome information resources. (8 Periods)
  2. Functional Proteomics - protein sequence and structural data, protein information resources and secondary data bases. (8 Periods)
  3. Computational Genomics - Internet basics, biological data analysis and application, sequence data bases, NCBI model, file format. (8 Periods)
  4. Sequence alignment & data base search - Protein primary sequence analysis, DNA sequence analysis, pair wise sequence alignment, FASTA algorithm, BLAST, multiple sequence alignment, DATA base searching using BLAST and FASTA. (10 Periods)
  5. Structural data bases - Small molecules data bases, protein information resources, protein data bank. (8 Periods)

Paper Code : BDT–403 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Biodiversity & Taxonomy
Lecture period : 42L

  1. Basic concept of Biodiversity – What is Biodiversity, Why should we conserve it, Elements of Biodiversity - Ecosystem Diversity, Genetic Diversity, Species Abundance & Diversity, Patterns of Species Diversity. (4 Periods)
  2. Global patterns of Biodiversity – measuring biodiversity, Cataloging and Discovering Species, Geographical Patterns of Species Richness, Biogeography, Importance of Distribution Patterns (Local Endemics, Sparsely Distributed Species, Migratory Species), GAP Analysis. (5 Periods)
  3. Biodiversity & Conservation – Overexploitation threatening living species, International Trade, Animals threatened by International trade, Problems in Controlling International Trade (Enforcement, Reservations, Illegal Trade), Free Trade & the Environment, Free Trade & Conservation, Common patterns of Overexploitation. (5 Periods)
  4. Exotic Species – Plants, Invertebrates, Fishes, Amphibians, Reptiles, Birds, Mammals, Detrimental Effects of Exotic Species. (3 Periods)
  5. Endangered Species Conservation – The US Endangered Species Act, State Endangered Species Acts Successes and Failures of the Endangered Species Act Role of ESA in Habitat Protection, Critical Habitat, Problems with the Endangered Species Act, Habitat Conservation Plans. (5 Periods)
  6. Ethics of Conservation – Values of Biodiversity, Biopiracy, Hybridized plants, GM crops (benefits & criticism), Economic Value of Biodiversity & Legal, Ethical and Conservation issues related to uses of biodiversity, Global Conservation Issues. (4 Periods)
  7. Basic concept of Taxonomy – Classification, Construction of Phylogenetic tree, Systematics, Cladistics, Cladograms, Phenetics, Nomenclature. (5 Periods)
  8. Taxonomy in relation to Chromosomal morphology & Evolution – Chromosomal evolution, why location of genes matter, evolutionary oddities about chromosomes, evolutionary effect of rearrangements of chromosomes, karyotypic orthoselection, chromosomal evolution & speciation. (5 Periods)
  9. Molecular Taxonomy in relation to DNA characteristics & Protein sequences – modes of molecular evolution, Neutral theory of Molecular evolution, genetic markers for taxonomic purposes, comparing total genome by DNA-DNA hybridization, comparing DNA sequences, Cladistics, biological identification through DNA barcodes, chromosome painting, establishing molecular homology using protein sequences. (6 Periods)

Paper Code : DEG -404 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Developmental Genetics
Lecture period : 42L

  1. Principles of Developmental Biology - Genetic approaches, Genetic marking, Genetic malformations. (3 Periods)
  2. Developmental patterns – Developmental dynamics of cell specification (Autonomous, Syncytial & Conditional), Morphogenetic fields. (4 Periods)
  3. The Genetic core of development - The Embryological origins of Gene Theory, Early attempts at Developmental Genetics, Genomic equivalence, determining the function of genes during development, Gene targeting (Knockout) experiments, determining function of a message : Antisense RNA. (6 Periods)
  4. Genetics of cell-cell communication in development - JAK-STAT pathway, Hedgehog pathway, ‘Canonical’ WNT pathway, “non-Canonical” WNT pathway, SMAD pathway, cell death pathways, Juxtacrine signaling & Cell patterning. (6 Periods)
  5. Differential gene expression from the same nuclear repertoire – differential gene transcription, selective nuclear RNA processing, Selective mRNA translation, differential protein modification, DNA methylation & gene activity, chromatin modification induced by DNA methylation, dosage compensation, X-inactivation in Human female, miRNA in transcriptional gene regulation. (6 Periods)
  6. Environmental regulation of Animal development – Phenotypic plasticity, Environment – as part of normal development, Polyphenisms & Plasticity, environmentally adaptive nervous system, Endocrine disruptors. (4 Periods)
  7. Developmental mechanisms of Evolutionary change – ‘Unity of Type & ‘Conditions of Existence’, preconditions for Macroevolution through developmental change – Modularity & Molecular parsimony, mechanisms of macroevolutionary change, Homologous pathways of development, Developmental constraints (Physical, Morphogenetic & Phyletic). (4 Periods)
  8. Genetic analysis of developmental pathways in model organisms – Drosophila, C. elegans, Xenopus, Zebrafish, Chick & Mouse. (6 Periods)
  9. Genetics of Metamorphosis, Regeneration & Aging – Metamorphosis in Insects, Metamorphosis in Amphibia, Morphallactic Regeneration in Hydra, Epimorphic regeneration of Salamander limbs, Compensatory regeneration in the Mammalian Liver, Causes of Aging, Genetically regulated pathway of Aging. (5 Periods)
  10. Medical implications of Developmental Biology – Genetic errors of Human development, inborn errors of nuclear RNA processing & translation, identifying the genes for Human developmental anomalies, Teratogenesis – environmental assaults on Human development. (6 Periods)

Paper Code : MBT–491 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Molecular Biology Techniques
Practical period : 40

  1. DNA isolation - from Plant cell (leaf of cabbage / mustard), Animal cell (goat liver), Human Blood (Fresh / Stored / Frozen) & Microbes (12 Periods)
  2. Plasmid DNA isolation (6 Periods)
  3. Gel electrophoresis (10 Periods)
  4. Polymerase Chain Reaction (8 Periods)
  5. Gel documentation & photography (4 Periods)

Paper Code : BIN–492 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Bio-informatics
Practical period : 40

  1. Internet basics (10 Periods)
  2. Introduction to NCBI Web sites (15 Periods)
  3. Introduction to Data bases (15 Periods)

Fifth Semester Syllabus

Paper Code : DPB-501 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : DNA Typing, Proteomics & Beyond
Lecture period : 42L

  1. DNA Typing : DNA polymorphisms: the basis of DNA typing, Minisatellite analysis, Polymerase chain reaction based analysis, Short tandem repeat analysis, Mitochondrial DNA analysis, Y chromosome analysis, Randomly amplified polymorphic DNA (RAPD) analysis. (10 Periods)
  2. Proteomics and beyond : Analysis of the transcriptome, Proteomics-Expression analysis & Characterization of proteins, Metabolomics & global biochemical networks. (12 Periods)
  3. High-throughput analysis of gene function - DNA microarrays, Protein arrays, Mass spectrometry. (10 Periods)
  4. Single Nucleotide Polymorphisms - The nucleolar proteome, Mapping disease-associated SNPs : Alzheimer’s disease. (10 Periods)

Paper Code : RDT-502 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Recombinant DNA Technology
Lecture period : 42L

  1. Gene Recombination and Gene transfer : Bacterial Conjugation, Transformation, Transduction, Episomes, Plasmids, Microinjection, Electroporation, Microprojectile, Shot Gun method, Ultrasonication, Liposome fusion, Microlaser. (8 Periods)
  2. Changing genes: site-directed mutagenesis and Protein engineering: Primer extension is a simple method for site directed mutation, PCR based site directed mutagenesis, Random mutagenesis, Use of Phage display techniques to facilitate the selection of mutant peptides, Gene shuffling, production of chimeric proteins. (10 Periods)
  3. Genetic engineering in animals: Production of transgenic mice, ES cells can be used for gene targeting in mice, Applications of gene targeting, Using Yeast to study Eukaryotic gene function, Therapeutic products produced by genetic engineering-blood proteins, human hormones, immune modulators and vaccines, Transgenic animals, Production of proteins of Pharmaceutical value. (12 Periods)
  4. Genetic engineering in plants: Use of Agrobacterium tumefaciens and Arhizogenes, Ti plasmids, Strategies for gene transfer to plant cells, Direct DNA transfer to plants, Gene targeting in plants, Use of plant viruses as episomal expression vectors. (12 Periods)

Paper Code : EVB-503 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Environmental Biotechnology
Lecture period : 42L

  1. Components of Environment – Hydrosphere, lithosphere, atmosphere and biosphere – definitions with examples; Interaction of man and environment; Environmental Studies as a multidisciplinary subject. (4 periods)
  2. Global Environmental Problems – Green House Effect, Acid rain, El Nino, Ozone depletion, deforestation, desertification, salination, biodiversity loss; chemical and radiation hazards. (4 periods)
  3. Environmental pollution and degradation – Pollution of air, water and land with reference to their causes, nature of pollutions, impact and control strategies; noise pollution; environmental damage by agriculture, perspectives of pollution in urban, industrial and rural areas. Habitat Pollution by Chlorinated Hydrocarbons (DDT, PCBs, Dioxin etc), Organophosphates, Heavy Metals, Die-offs, Endocrine disrupting chemicals, Nutrient pollution. (10 periods)
  4. Environmental Management – Concept of health and sanitation, environmental diseases – infectious (water and air borne) and pollution related, spread and control of these diseases, health hazards due to pesticide and metal pollution, waste treatment, solid waste management, environmental standards and quality monitoring. (6 periods)
  5. Environmental Protection Act – Environmental Laws, national movements, sustainable development, environmental policies, environmental economics, environmental ethics – holistic approach of environmental protection and conservation, IUCN – role in environmental protection. Concept with reference to UN – declaration, aim and objectives of human right policies with reference to India, recent north-south debate on the priorities of implementation, Environmental Protection Agency (EPA). (10 periods)
  6. Bioremediation – Oil spills, Wastewater treatment, chemical degradation, heavy Metals. (8 periods)

Paper Code : GEM-504 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Genetic Modification in Agriculture, Food Industry and Medicine
Lecture period : 42L

  1. Genetic modification – terminology, methods of genetic modification, genetic modification of bacteria, plant & animal, controversies over genetic modification, policy around the world (USA, European Union, EU regulation, Japan, China & other developing countries). (12 Periods)
  2. Genetic modification in Agriculture – transgenic plants, genetically modified foods, application, future applications, ecological impact of transgenic plants. (10 Periods)
  3. Genetically modified foods – organic foods, types of organic foods, identifying organic foods, organic food & preservatives. (6 Periods)
  4. Genetic modification in Food industry – background, history, controversies over risks, application, future applications. (6 Periods)
  5. Genetic modification in Medicine - gene therapy, types of gene therapy, vectors in gene therapy, molecular engineering, human genetic engineering, problems & ethics. (8 Periods)

Paper Code : GTT–591 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Genetic Toxicity Testing
Practical period : 40

  1. Short-Term Biochemical Tests for Genetic Toxicity (10 Periods)
  2. Test for gene mutations in bacteria - Bacterial Reverse Mutation Test (10 Periods)
  3. In vitro test with cytogenetic evaluation of chromosomal damage (Chromosomal Aberration study) using mammalian (Lab. Mouse) cells (10 Periods)

Paper Code : MCG–592 (Practical)
Full Marks : 100
Credit = 2
Paper Name : Molecular Cyto-Genetics
Practical period : 40

  1. FISH (Fluorescence in situ Hybridization) to Metaphase Chromosomes (10 Periods)
  2. High Resolution FISH analysis (10 Periods)
  3. CGH (Comparative Genomic Hybridization) analysis (10 Periods)

Sixth Semester Syllabus

Paper Code : MHG-601 (Theoretical)
Full Marks : 100
Credit : 4 (3+1) Lecture period : 42L
Paper Name : Model Organisms in Human Genome Project

  1. Genome – about genomes of model organisms (E. coli, Yeast, Arabidopsis thaliana, C. elegans, Drosophila melanogaster, laboratory mouse, Zebra fish, Human), types of genomes, genomes & genetic variation, comparison of different genomes, genome evolution. (8 Periods)
  2. Genomics – about the genomics, history, comparative genomics, comparative genomic hybridization, functional genomics. (5 Periods)
  3. Genome projects – an overview of genome projects of human and other model organisms of Human Genome Project. (5 Periods)
  4. Human Genome Project (HGP) – an overview of the project, goals of the project, major scientific strategies & approaches used in HGP, expected scientific & medical benefits of this project, about the organizations behind this project. (8 Periods)
  5. How Human genome was mapped – physical mapping, genetic mapping, gene ontology, gene annotation. (8 Periods)
  6. Technologies used in HGP – RFLP, microsatellite markers, STS, EST, DNA sequencing, DNA microarray. (8 Periods)

Paper Code : RCG -602 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Reproductive & Cancer Genetics
Lecture period : 42L

  1. Sex-determination & Dosage compensation – patterns, Sex determination in Flowering plants, C. elegans, Drosophila & Human, Single gene control of sex, Genic Balance theory, Sex differentiation & Dosage compensation, Dosage compensation in Drosophila, C. elegans & Human. (6 Periods)
  2. Reproductive Genetics – genetics of sex determination & sexual differentiation, reproductive technologies, artificial insemination, cryo-preservation of oocyte, sperm & embryo, in vitro fertilization, embryo transfer, intra-cytoplasmic sperm injection, ethical issues, prenatal diagnosis, pre-implantation genetic diagnosis (PGD), Genetic technologies used in PGD, Genetic causes of male and female infertility, use of PGD & cloning in infertility. (10 Periods)
  3. Reproductive Technologies - Artificial insemination in livestock and pets, Human Artificial Insemination. (6 Periods)
  4. Cancer Genetics – characteristics of normal cells, benign tumor cells, and malignant tumor cells, Oncogenes, activation of proto-oncogenes, Tumor suppressor genes, control of the cell cycle, control of the integrity of the genome, Tumor Suppressor pathways (The p16-cyclin D-pRb-E2F pathway, The p19ARF-Mdm2-p53 pathway), mutations in oncogenes and suppressor genes which are thought to contribute to malignant transformation, genetics of sporadic, familial, and hereditary cancers, Inherited Cancer syndromes, genetic testing for cancer syndromes, current and potential roles of gene therapy for cancer, Interpret pedigrees to identify people at increased risk for cancer development, multi-step evolution of cancer. (20 Periods)

Paper Code : MLG -603 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Molecular Human Genetics
Lecture period : 42L

  1. Genetic mapping of Mendelian characters: Recombinants, Non-recombinants, Genetic markers, Two point mapping, Multipoint mapping, Fine mapping using extended pedigrees and ancestral haplotypes. (10 Periods)
  2. Identifying Human disease genes: Principles and strategies in identifying disease genes, Positional cloning, Use of chromosomal abnormalities, confirming a candidate gene, various ways of identifying disease genes. (10 Periods)
  3. Mapping and identifying genes conferring susceptibility to complex diseases: Deciding whether a non-Mendelian character is genetic: the role of family, twin and adoption studies, Linkage analysis of complex characters, Association studies and linkage disequilibrium, Identifying the susceptibility alleles, Examples that illustrate the varying success of genetic dissection of complex diseases. (12 Periods)
  4. Molecular Pathology: Rules for nomenclature of mutations & databases of mutations, Loss of function mutations, Gain of function mutations, Molecular pathology from gene to disease, Molecular pathology from disease to gene, Molecular pathology of chromosomal disorders. (10 Periods)

Paper Code : GLE-604 (Theoretical)
Full Marks : 100
Credit : 4 (3+1)
Paper Name : Genetic Technology : Social, Legal & Ethical Issues
Lecture period : 42L

  1. Genetic technologies – an overview of Genetic screening for any predisposition symptoms, Cancer screening, Cloning, Gene therapy, DNA fingerprinting,(Paternity and Forensics) in vitro fertilization, surrogate motherhood, PGD, transgenic organisms, xenotransplantation, GMOs. (10 Periods)
  2. Social issues - public opinions against the molecular technologies. (6 Periods)
  3. Legal issues – legal actions taken by countries for use of the molecular technologies. (6 Periods)
  4. Ethical issues – ethical issues against the molecular technologies. (6 Periods)
  5. Bioethics – Necessity of Bioethics, different paradigms of Bioethics – National & International. (6 Periods)
  6. Intellectual Property Rights – Why IPR is necessary, TRIPS & IPR, IPR – national & international scenario, IPR protection of life forms. (8 Periods)

Paper Code : PRO–691 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Project on Biodiversity
Tour : 3-5 days (40 hrs)

  • A project work should be done individually or in a group under the guidance of one faculty of IGE on any topic related to the subject after one Educational tour to any place of India. The duration of tour will be at least 3-5 days at the spot depending upon the information/sample collection of project work. The work will be documented & also presented by the candidate in front of externals in a seminar.

Paper Code : DSS–692 (Practical)
Full Marks : 100
Credit : 2
Paper Name : Dissertation on Genetics
Lab. work : 40 hrs

  • A project work should be done individually under the guidance of one faculty of IGE on any topic related to the subject & can be recorded as dissertation & also be presented by the candidate in front of externals in a seminar.

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